Neurocognitive Endophenotypes for Bipolar Disorder Identified in Multiplex Multigenerational Families
نویسندگان
چکیده
منابع مشابه
Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families.
CONTEXT Although genetic influences on bipolar disorder are well established, localization of genes that predispose to the illness has proven difficult. Given that genes predisposing to bipolar disorder may be transmitted without expression of the categorical clinical phenotype, a strategy for identifying risk genes is to identify and map quantitative intermediate phenotypes or endophenotypes. ...
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Certain cognitive measures are heritable and differentiate individuals at risk for schizophrenia from unaffected family members and healthy comparison subjects. These deficits in neurocognitive performance in patients with schizophrenia appear stable in the short-term. However, the duration of most, but not all, longitudinal studies is modest and the majority have relied on traditional average ...
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Endophenotypes (intermediate phenotypes) are objective, heritable, quantitative traits hypothesized to represent genetic risk for polygenic disorders at more biologically tractable levels than distal behavioural and clinical phenotypes. It is theorized that endophenotype models of disease will help to clarify both diagnostic classification and aetiological understanding of complex brain disorde...
متن کاملShared and Distinct Neurocognitive Endophenotypes of Schizophrenia and Psychotic Bipolar Disorder
OBJECTIVE Schizophrenia and bipolar disorder are characterized by the presence of neurocognitive impairments on the psychosis continuum. The present study aimed to explore the shared and distinct endophenotypes between these disorders. METHODS The study included 34 probands with remitted schizophrenia and 34 probands with euthymic bipolar disorder who had a history of psychotic symptoms that ...
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INTRODUCTION There are a lot of unresolved issues associated with the classification, diagnosis, clinical management and understanding of the underlying pathogenic mechanisms of bipolar affective disorder. AIM To search for discrete endophenotypes in BAD. SUBJECTS AND METHODS We studied various bipolar I and II and recurrent depression patient samples and healthy controls using descriptive ...
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ژورنال
عنوان ژورنال: Archives of General Psychiatry
سال: 2010
ISSN: 0003-990X
DOI: 10.1001/archgenpsychiatry.2009.184